<cms_index_defaultnoroute>
        <remove name="right"/>
        <remove name="left"/>
        
        <reference name="root">
            <action method="setTemplate">
                <template>page/1column.phtml</template>
            </action>
        </reference>
        <reference name="content">
            <block type="core/template" name="default_no_route" template="cms/default/no-route.phtml"/>
        </reference>
    </cms_index_defaultnoroute>